The internet is now becoming the most substantial source of online jobs which actually pay. Because of the immense capability of such technology to send and receive information, you may now equip yourself with some of the most relevant directories of legitimate online jobs. There are practically hundreds of internet based companies which enables their members to earn a good amount of money just by doing some very easy tasks over the internet.
How does an ordinary person like you get an online job opportunity? In many cases, legitimate online jobs are very visible if you just happen to be persistent enough to find those valued links. You may search through a wide array of linking websites in order to catch the most credible sites which offer a stable source of income. You must realize that choosing a legit website does not necessarily equate to substantial convenience on your part. You should always be aware of the tasks and the process of completing the tasks involved. There are many cases wherein people tend to lose their positions online because of their incapability to complete the required tasks.
There are numerous ways on how to start an online writing career in which you may apply to. However, the most popular ones right now are those sites which let you write articles, essays and research projects. This is more like of outsourcing your talents in writing in order for you to come up with a very stable job. You may look into considering applying for online jobs. You may read on some very important info which will address your questions about . The step by step application can be first introduced on a freelance writing page of your chosen website.
What are the primary aspects to consider when you get the idea of working at home? First, you must be confident with yourself in expressing your thoughts and ideas in the English language. Apparently, most customers who avail of the writing services are college, high school and professional students. The use of a very good command in the language makes a perfect tool in addressing the academic research needs of the client.
Second, you must at least know some citation styles in writing your research papers. The most common types are the APA, MLA and Harvard citation styles. These are among the top choices of academicians in writing their term and dissertation articles.
Thirdly, you must be responsible enough to meet the requirements of the clients you are rendering your service to. There is a certain deadline, paper format and research tools that should be met prior to submitting the completed work. You should also be aware that a good communication with the ordering customer will be beneficial in assigning the correct features of the article.
If you want to check out the kind of writing jobs which you may have, you can search for some more freelance writing opportunities. This process will explain to you everything you need to know and expect in handling jobs online. This may be the start of a fulfilling career for you as an online writer.
السبت، 26 أبريل 2008
Free online training course
who from us do not want to be proffesional in computer and internet upon navigating in the internet i find this interesting site which offer free courses online
http://www.e-learningcenter.com/free.htm
Dynamic HTML - Using JavaScript
Free UNIX Training Course
Unix - Shell Programming
Free Investing Fundamentals Training Course
Investing Fundamentals - Organizing
Free Negotiating Training Course
Negotiating - Closing the Deal
Free Customer Service Training Course
Customer Service - Communicatiing
Free HTML Training Course
HTML - Start Creating Your Own Web Pages
Free Windows 2000 Server Training Course
Windows 2000 Server - Controlling Access to Files & Folders
Free Excel 2000 MOS Training Course
Excel 2000 MOS - Working With Cells
Take one...or take them all! Try our online learning today, FREE!
It's Easy
Fill in the simple registration form below.
Click the "Submit Registration" button.
A e-mail will be sent to the e-mail address you use to register.
Click the link in the confirmation e-mail to confirm your registration.
This link will take you to the Free Courses Gateway page.
Add this page to your favorites to be able to return to the free courses as much as you'd like.
.
Begin taking your free course.
And It's FREE!
Try a free online training course to see for yourself the quality of training that is offered at these unbelievable prices. Fill out the simple registration form below to get to our Free Course site. You'll have a choice of several free complete courses to take.
Your privacy is important to us! Be assured that your name and e-mail information are not sold or given to any third party advertisers, ever!
http://www.e-learningcenter.com/free.htm
Dynamic HTML - Using JavaScript
Free UNIX Training Course
Unix - Shell Programming
Free Investing Fundamentals Training Course
Investing Fundamentals - Organizing
Free Negotiating Training Course
Negotiating - Closing the Deal
Free Customer Service Training Course
Customer Service - Communicatiing
Free HTML Training Course
HTML - Start Creating Your Own Web Pages
Free Windows 2000 Server Training Course
Windows 2000 Server - Controlling Access to Files & Folders
Free Excel 2000 MOS Training Course
Excel 2000 MOS - Working With Cells
Take one...or take them all! Try our online learning today, FREE!
It's Easy
Fill in the simple registration form below.
Click the "Submit Registration" button.
A e-mail will be sent to the e-mail address you use to register.
Click the link in the confirmation e-mail to confirm your registration.
This link will take you to the Free Courses Gateway page.
Add this page to your favorites to be able to return to the free courses as much as you'd like.
.
Begin taking your free course.
And It's FREE!
Try a free online training course to see for yourself the quality of training that is offered at these unbelievable prices. Fill out the simple registration form below to get to our Free Course site. You'll have a choice of several free complete courses to take.
Your privacy is important to us! Be assured that your name and e-mail information are not sold or given to any third party advertisers, ever!
الاثنين، 21 أبريل 2008
free passwords
Dear friends: Do you know how to find out database quickly without
entering so many university libraries and search the web again and
again? Do you know what databases does a library have? You will
recommend google search engine, but does it provide you enough and
prcise information? No!So this handbook for you guys as an index of
library resource menu, for you to get to any database or journal
without entering lots of university librares. contact:
www.passfans. com
entering so many university libraries and search the web again and
again? Do you know what databases does a library have? You will
recommend google search engine, but does it provide you enough and
prcise information? No!So this handbook for you guys as an index of
library resource menu, for you to get to any database or journal
without entering lots of university librares. contact:
www.passfans. com
الخميس، 17 أبريل 2008
Techniques for Searching Databases of Three-Dimensional (3D) Structures with Receptor-Based Queries
Ligand-based vs. Receptor-based 3D Searching
A key concept in 3D searching is the pharmacophore. The term, introduced by Ehrlich in the early 1900s , refers to the molecular framework that carries (phoros) the essential features responsible for a drug's (pharmacon) biological activity. In the current literature, the term has been expanded to refer to the 3D arrangement of functional groups that enable a compound to exert a particular biological effect. Due to stereochemical considerations (i.e., three-point attachments), many pharmacophores are defined simply in terms of three atoms and three distances. If more information is available, other geometric objects and constraints can be added, including constraints on data associated with atoms and bonds . Presently, most pharmacophores are defined in terms of the atoms and bonds of the ligand structures. This ligand-based definition has advantages for input and searching purposes; in the case where the structure of the receptor is completely unknown, it is the only way one can effectively define a pharmacophore model.
It is clear that drugs that bind to a common receptor do not necessarily bind with similar functional groups precisely overlapped; rather, these drugs may show multiple modes of binding . The interactions between a drug molecule and a receptor can be dispersed and nonspecific, as in steric and lipophilic interactions - which nevertheless account for most of the free energy changes in binding . Alternatively, they can be highly specific and directional, such as interactions involving H-bond donors and acceptors or those with bound metal ions. But even then, precise overlap of heteroatoms may not result, since the specific interactions occur over a range of angles, distances, and energies .
Clearly, in such cases, a receptor-based approach to a pharmacophore definition is needed to carry key features of the receptor involved in drug molecule binding. A full receptor-based pharmacophore model complements the ligand-based pharmacophore model for the same activity; it is the 'lock' for a given 'key.' This concept has been expressed and utilized previously, as in the extended molecule approach of Andrews . Our purpose is to show how to implement receptor-based queries in a pharmacophore-based 3D search system. We will also evaluate the success of these queries with respect to their pharmacophoric counterparts by testing them on a database of drugs with known activities.
A key concept in 3D searching is the pharmacophore. The term, introduced by Ehrlich in the early 1900s , refers to the molecular framework that carries (phoros) the essential features responsible for a drug's (pharmacon) biological activity. In the current literature, the term has been expanded to refer to the 3D arrangement of functional groups that enable a compound to exert a particular biological effect. Due to stereochemical considerations (i.e., three-point attachments), many pharmacophores are defined simply in terms of three atoms and three distances. If more information is available, other geometric objects and constraints can be added, including constraints on data associated with atoms and bonds . Presently, most pharmacophores are defined in terms of the atoms and bonds of the ligand structures. This ligand-based definition has advantages for input and searching purposes; in the case where the structure of the receptor is completely unknown, it is the only way one can effectively define a pharmacophore model.
It is clear that drugs that bind to a common receptor do not necessarily bind with similar functional groups precisely overlapped; rather, these drugs may show multiple modes of binding . The interactions between a drug molecule and a receptor can be dispersed and nonspecific, as in steric and lipophilic interactions - which nevertheless account for most of the free energy changes in binding . Alternatively, they can be highly specific and directional, such as interactions involving H-bond donors and acceptors or those with bound metal ions. But even then, precise overlap of heteroatoms may not result, since the specific interactions occur over a range of angles, distances, and energies .
Clearly, in such cases, a receptor-based approach to a pharmacophore definition is needed to carry key features of the receptor involved in drug molecule binding. A full receptor-based pharmacophore model complements the ligand-based pharmacophore model for the same activity; it is the 'lock' for a given 'key.' This concept has been expressed and utilized previously, as in the extended molecule approach of Andrews . Our purpose is to show how to implement receptor-based queries in a pharmacophore-based 3D search system. We will also evaluate the success of these queries with respect to their pharmacophoric counterparts by testing them on a database of drugs with known activities.
الجمعة، 11 أبريل 2008
Learning Chemistry Online
Chemistry is one of those hands on subjects that is probably extremely hard to Learn online. Though, I have run in to some pretty neat lessons around the internet that can teach you some general chem knowledge. Do you think high school students would enjoy this kind of thing? Or to expand on that, do you think they could use these kind of online educational resources as a homework tool?
Here is a pretty cool lesson:
http://learnhub.com/lesson/page/118-creating-colored-flames
Here is a pretty cool lesson:
http://learnhub.com/lesson/page/118-creating-colored-flames
Check out Tripos Discovery Drugs
www.tripos.com
Well-designed and frequently updated software can save valuable time
and often means the difference between success and failure. Tripos'
premier computational informatics offering, SYBYL, leads the way in
innovation with its ever-growing suite of technologies and our
commitment to applied science and frequent product enhancements
Surflex-Dock
Ligand-Receptor Docking and Virtual Screening
Now Available Fully Integrated with SYBYL® 7.2!
Overview
Screening large compound libraries remains an expensive and time-
consuming task. Computational high-throughput screening can enrich
the fraction of suitable compounds in a screening collection,
thereby reducing the cost of biological testing in lead discovery.
Surflex-Dock offers unparalleled enrichments in virtual high-
throughput screening combined with state-of-the-art speed, accuracy
and usability. It uses an updated and re-parameterized empirical
scoring function (based on the Hammerhead docking system) with
additional negative training data and a search engine that relies on
a surface-based molecular similarity method.
Surflex-Dock has been extensively validated and favorably compared
to all leading competing methods by independent researchers
(Kellenberger et al., (2004) Proteins: Structure, Function, and
Bioinformatics 57, 225-242), along with 28 other studies by the
applications author, Prof. Ajay N. Jain, Ph.D., a faculty member at
the University of California San Francisco Cancer Research
Institute.
"Surflex-Dock couples a unique scoring function with a patented
state-of-the-art search engine. The combination has been shown to
yield excellent results in terms of docking accuracy, and
distinctively superior results in terms of screening enrichment,"
said Prof. Ajay N. Jain.
DISCOVERY INFORMATICS
SYBYL®
Benchware®
Informatics Research Center
Platform Technologies
Informatics Services
DISCOVERY RESEARCH
LeadDiscovery™
Discovery Chemistry
Screening Libraries
Research Partnerships
Knowledge-Driven Process
Well-designed and frequently updated software can save valuable time
and often means the difference between success and failure. Tripos'
premier computational informatics offering, SYBYL, leads the way in
innovation with its ever-growing suite of technologies and our
commitment to applied science and frequent product enhancements
Surflex-Dock
Ligand-Receptor Docking and Virtual Screening
Now Available Fully Integrated with SYBYL® 7.2!
Overview
Screening large compound libraries remains an expensive and time-
consuming task. Computational high-throughput screening can enrich
the fraction of suitable compounds in a screening collection,
thereby reducing the cost of biological testing in lead discovery.
Surflex-Dock offers unparalleled enrichments in virtual high-
throughput screening combined with state-of-the-art speed, accuracy
and usability. It uses an updated and re-parameterized empirical
scoring function (based on the Hammerhead docking system) with
additional negative training data and a search engine that relies on
a surface-based molecular similarity method.
Surflex-Dock has been extensively validated and favorably compared
to all leading competing methods by independent researchers
(Kellenberger et al., (2004) Proteins: Structure, Function, and
Bioinformatics 57, 225-242), along with 28 other studies by the
applications author, Prof. Ajay N. Jain, Ph.D., a faculty member at
the University of California San Francisco Cancer Research
Institute.
"Surflex-Dock couples a unique scoring function with a patented
state-of-the-art search engine. The combination has been shown to
yield excellent results in terms of docking accuracy, and
distinctively superior results in terms of screening enrichment,"
said Prof. Ajay N. Jain.
DISCOVERY INFORMATICS
SYBYL®
Benchware®
Informatics Research Center
Platform Technologies
Informatics Services
DISCOVERY RESEARCH
LeadDiscovery™
Discovery Chemistry
Screening Libraries
Research Partnerships
Knowledge-Driven Process
الاثنين، 7 أبريل 2008
Virtual Textbook of Organic Chemistry
very interesting site about basic organic chemistry hope to make use of it
http://www.cem.msu.edu/%7Ereusch/VirtualText/intro1.htm
http://www.cem.msu.edu/%7Ereusch/VirtualText/intro1.htm
Online degrees & courses
There are many choices available and this is right aproach that first research about degree and than get one.
Master, Bachelor, Associate and Phds:
http://www.degreexs .com/?aff= 4837
http://courtneytuttle.com/2007/02/25/starting-a-blog-in-5263-words/
Master, Bachelor, Associate and Phds:
http://www.degreexs .com/?aff= 4837
http://courtneytuttle.com/2007/02/25/starting-a-blog-in-5263-words/
الثلاثاء، 1 أبريل 2008
Teaching Style
Teaching Style
In education generally (in the UK and elsewhere) there seems to be a swing back to "traditional" methods of teaching. The progressive ideas that evolved from the self-discovering sixties are giving way to a more pedagogical style. Whilst this approach may well be appropriate to junior & intermediate levels, particularly in the sciences, students in higher education still need to be encouraged to think for themselves if society wishes properly to develop its human and environmental resources.
The Chemistry Education: Research and Practice site offers very interesting articles on this theme. The following extract from the paper by Uri Zoller is found particularly pertinent:-
Environmental sciences are emerging as a new interdisciplinary scientific “discipline”, … within a process of distancing from specialized, compartmentalized, and disciplinary, into multidimensional, cross-boundary endeavor in the science-technology-environment society (STES) interfaces. This poses new challenges with respect to the intrinsic science and technology organization and to the way the relevant knowledge and processes will be put into action …
The essence of the current reform in science/chemical education, worldwide, is a paradigm shift from algorithmic/imparting knowledge-type teaching to higher-order cognitive skills (HOCS) learning. In the context of education in environmental chemistry (EEC), the ultimate target is the STES-literate graduate, capable of evaluative thinking, decision making, problem solving and taking a responsible action accordingly. …
…Environmental literacy requires the integration of environmental sciences into core chemical courses as well as the development and implementation of HOCS-promoting teaching strategies and assessment methodologies in chemical education …(and) The development of students’ HOCS for transfer, followed by assessment of ‘HOCS performance’; is the task ahead for meaningful EEC…
…
Ensuring sustainable development requires, .. a radical change in the “environmental behavior” and “thinking environment” of individuals, groups, institutions, industry, social organizations, politicians, and governments. Therefore, HOCS learning constitutes a prerequisite. … The question is how to contribute to this end in the context of chemistry and environmental education.
In view of the above, a ‘call for papers’ for a special Theme Issue of Chemistry Education: Research and Practice (CERP) was issued, inviting contributions on the theme of chemistry and environmental education of two kinds: (a) research based; (b) practice-oriented papers …
…
This peer-reviewed Special Theme Issue .. consists of seven papers, contributed by Eichler, Lubezky, Morgil, Petrou, Schallies, Scoullos, Tal et al., constituting a spectrum of appropriate responses to the above subjects in different contexts. As such, they contribute meaningfully, so we believe, to the research, theory and practice in chemistry and environmental education, education in environmental chemistry and STES-oriented science education. The time is ripe for taking action accordingly in chemistry education.
In education generally (in the UK and elsewhere) there seems to be a swing back to "traditional" methods of teaching. The progressive ideas that evolved from the self-discovering sixties are giving way to a more pedagogical style. Whilst this approach may well be appropriate to junior & intermediate levels, particularly in the sciences, students in higher education still need to be encouraged to think for themselves if society wishes properly to develop its human and environmental resources.
The Chemistry Education: Research and Practice site offers very interesting articles on this theme. The following extract from the paper by Uri Zoller is found particularly pertinent:-
Environmental sciences are emerging as a new interdisciplinary scientific “discipline”, … within a process of distancing from specialized, compartmentalized, and disciplinary, into multidimensional, cross-boundary endeavor in the science-technology-environment society (STES) interfaces. This poses new challenges with respect to the intrinsic science and technology organization and to the way the relevant knowledge and processes will be put into action …
The essence of the current reform in science/chemical education, worldwide, is a paradigm shift from algorithmic/imparting knowledge-type teaching to higher-order cognitive skills (HOCS) learning. In the context of education in environmental chemistry (EEC), the ultimate target is the STES-literate graduate, capable of evaluative thinking, decision making, problem solving and taking a responsible action accordingly. …
…Environmental literacy requires the integration of environmental sciences into core chemical courses as well as the development and implementation of HOCS-promoting teaching strategies and assessment methodologies in chemical education …(and) The development of students’ HOCS for transfer, followed by assessment of ‘HOCS performance’; is the task ahead for meaningful EEC…
…
Ensuring sustainable development requires, .. a radical change in the “environmental behavior” and “thinking environment” of individuals, groups, institutions, industry, social organizations, politicians, and governments. Therefore, HOCS learning constitutes a prerequisite. … The question is how to contribute to this end in the context of chemistry and environmental education.
In view of the above, a ‘call for papers’ for a special Theme Issue of Chemistry Education: Research and Practice (CERP) was issued, inviting contributions on the theme of chemistry and environmental education of two kinds: (a) research based; (b) practice-oriented papers …
…
This peer-reviewed Special Theme Issue .. consists of seven papers, contributed by Eichler, Lubezky, Morgil, Petrou, Schallies, Scoullos, Tal et al., constituting a spectrum of appropriate responses to the above subjects in different contexts. As such, they contribute meaningfully, so we believe, to the research, theory and practice in chemistry and environmental education, education in environmental chemistry and STES-oriented science education. The time is ripe for taking action accordingly in chemistry education.
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